کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5562765 | 1562707 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Further development of an in vitro model for studying the penetration of chemicals through compromised skin
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کلمات کلیدی
LSCEFSAOECDSCCsCompromised skinIn vitro percutaneous absorptionEuropean Food Safety Authority - اداره ایمنی اروپاbarrier function - تابع مانعOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهliquid scintillation counting - شمارش مایع شمعدانیElectrical resistance - مقاومت الکتریکیTape stripping - نوار سلب کردنScientific Committee on Consumer Safety - کمیته علمی ایمنی مصرف کننده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
A new in vitro model based on the electrical resistance properties of the skin barrier has been established in this laboratory. The model utilises a tape stripping procedure in dermatomed pig skin that removes a specific proportion of the stratum corneum, mimicking impaired barrier function observed in humans with damaged skin. The skin penetration and distribution of chemicals with differing physicochemical properties, namely; Benzoic acid, 3-Aminophenol, Caffeine and Sucrose has been assessed in this model. Although, skin penetration over 24Â h differed for each chemical, compromising the skin did not alter the shape of the time course profile, although absorption into receptor fluid was higher for each chemical. Systemic exposure (receptor fluid, epidermis and dermis), was marginally higher in compromised skin following exposure to the fast penetrant, Benzoic acid, and the slow penetrant Sucrose. The systemically available dose of 3-Aminophenol increased to a greater extent and the absorption of Caffeine was more than double in compromised skin, suggesting that Molecular Weight and Log Pow, are not the only determinants for assessing systemic exposure under these conditions. Although further investigations are required, this in vitro model may be useful for prediction of dermal route exposure under conditions where skin barrier is impaired.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 38, February 2017, Pages 101-107
Journal: Toxicology in Vitro - Volume 38, February 2017, Pages 101-107
نویسندگان
Diane J Davies, Jon R Heylings, Heather Gayes, Timothy J McCarthy, M Catherine Mack,