کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5585690 | 1568233 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acquisition of the pluripotent and trophectoderm states in the embryo and during somatic nuclear reprogramming
ترجمه فارسی عنوان
اکتسابی حالت های چند وجهی و تروتوکتروم در جنین و در طی برنامه ریزی هسته ای سمی
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
How the first cell fate decision of an embryo occurs is one of the most fascinating biological questions examined over the last few decades, with numerous in vivo models proposed and many factors tested for their role in the process. In this review, we will primarily focus on the mouse model and discuss the role that transcription factors play during establishment and maintenance of the first lineage segregation in the embryo, towards inner cell mass or trophectoderm. We will also overview recent developments in somatic nuclear reprogramming into induced pluripotent stem cells, the inner cell mass (epiblast) equivalent, and into induced trophoblast stem cells, the trophectoderm equivalent, and discuss potential correspondences between the in vivo and in vitro models.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Genetics & Development - Volume 46, October 2017, Pages 37-43
Journal: Current Opinion in Genetics & Development - Volume 46, October 2017, Pages 37-43
نویسندگان
Mohammad Jaber, Shulamit Sebban, Yosef Buganim,