کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5588636 | 1569102 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reduced water intake deteriorates glucose regulation in patients with type 2 diabetes
ترجمه فارسی عنوان
کاهش میزان مصرف آب باعث کاهش تنظیم گلوکز در بیماران مبتلا به دیابت نوع 2 می شود
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کلمات کلیدی
QUICKIHYPOGTTPRAAVPT2DMRAASACEOral glucose tolerance test - آزمون تحمل گلوکز خوراکیAldo - آلدوaldosterone - آلدوسترون Angiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمHomeostatic model assessment of insulin resistance - ارزیابی مدل هومستاتیک مقاومت به انسولینType 2 diabetes mellitus - دیابت نوع دوUSG - سونوگرافیRenin-angiotensin-aldosterone system - سیستم رنین-آنژیوتانسین-آلدوسترونbody mass index - شاخص توده بدنBMI - شاخص توده بدنیquantitative insulin sensitivity check index - شاخص کنترل حساسیت به انسولین کمیOsmolar concentration - غلظت اسمولارPlasma renin activity - فعالیت رنین پلاسماHypothalamic-pituitary axis - محور هیپوتالاموس-هیپوفیزHPA - میلی بار یا هکتوپاسکالDrinking - نوشیدن، آشامیدن، گساردنHyperglycemia - هایپرگلایسمیHOMA - هومvasopressin - وازوپرسینarginine vasopressin - وازوپرسین آرژینینUrine specific gravity - وزن مخصوص ادرارCORT - کورتcortisol - کورتیزول
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Epidemiological research has demonstrated that low daily total water intake is associated with increased diagnosis of hyperglycemia. Possible mechanisms for this increase include hormones related to the hypothalamic pituitary axis as well as the renin-angiotensin-aldosterone system (RAAS). Therefore, the hypothesis of the present study was that acute low water intake would result in differential hormonal profiles and thus impaired blood glucose regulation during an oral glucose tolerance test (OGTT) in people with type 2 diabetes mellitus (T2DM). Nine men (53 ± 9 years, 30.0 ± 4.3 mâkgâ2, 32% ± 6% body fat) diagnosed with T2DM completed OGTTs in euhydrated (EUH) and hypohydrated (HYP) states in counterbalanced order. Water restriction led to hypohydration of â1.6% of body weight, with elevated plasma (EUH: 288 ± 4, HYP: 298 ± 6 mOsm·kgâ1; P < .05) and urine (EUH: 512 ± 185, HYP: 994 ± 415 mOsm·kgâ1; P < .05) osmolality. There was a significant main effect of condition for serum glucose (at time 0 minute 9.5 ± 4.2 vs 10.4 ± 4.4 mmolâLâ1 and at time 120 minutes 19.1 ± 4.8 vs 21.0 ± 4.1 mmolâLâ1 for EUH and HYP, respectively; P < .001) but not insulin (mean difference between EUH and HYP â12.1 ± 44.9 pmolâLâ1, P = .390). An interaction between time and condition was observed for cortisol: decrease from minute 0 to 120 in EUH (â85.3 ± 82.1 nmolâLâ1) vs HYP (â25.0 ± 43.0 nmolâLâ1; P = .017). No differences between conditions were found within RAAS-related hormones. Therefore, we can conclude that 3 days of low total water intake in people with T2DM acutely impairs blood glucose response during an OGTT via cortisol but not RAAS-mediated glucose regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 43, July 2017, Pages 25-32
Journal: Nutrition Research - Volume 43, July 2017, Pages 25-32
نویسندگان
Evan C. Johnson, Costas N. Bardis, Lisa T. Jansen, J.D. Adams, Tracie W. Kirkland, Stavros A. Kavouras,