کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5588690 | 1404568 | 2016 | 45 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin C impacts anxiety-like behavior and stress-induced anorexia relative to social environment in SMP30/GNL knockout mice
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کلمات کلیدی
SMP30GluconolactonaseBDTGSHFSTNSFGNLforced swim test - آزمون شناور اجباریAnxiety - اضطرابAnorexia - بیاشتهاییanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceNovelty-suppressed feeding - تغذیه سرشار از نوآوریSocial environment - محیط اجتماعیStress Coping - مقابله با استرسknockout - ناکاوتwild type - نوع وحشیvitamin C - ویتامین سیGlutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The role of endogenous vitamin C (VC) in emotion and psychiatric measures has long been uncertain. We aimed to investigate how an individual's VC status impacts his or her mental health. Our hypothesis is that body VC levels modulate anxiety, anorexia, and depressive phenotypes under the influence of psychosocial rearing environments and sex. The VC status of senescence marker protein-30/gluconolactonase knockout mice, which lack the ability to synthesize VC, were continuously shifted from adequate (VC+) to depleted (VCâ) by providing a water with or without VC. Despite weight loss in both sexes, suppressed feeding was specifically seen in males only during the VCâ phase. Anxiety responses in the novelty-suppressed feeding paradigm were worse during the VCâ, especially in females. Sensitivity to the forced swim test as determined by the initial latency was significantly shorter in the socially stable animals compared with socially unstable animals during the VC+ condition. The stress coping underlying depressive phenotypes was assessed by immobility duration in a series of forced swim tests. No significant differences were apparent between contrasting VC status. Homeostatic symptoms following stressful behavioral tests consisted of a great loss of appetite during the VCâ. It should be noted that anorexia is extremely serious for the females. We conclude that endogenous VC status is critical for determining vulnerability to anxiety and anorexia in a sex-specific manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 36, Issue 12, December 2016, Pages 1379-1391
Journal: Nutrition Research - Volume 36, Issue 12, December 2016, Pages 1379-1391
نویسندگان
Miwako Koizumi, Yoshitaka Kondo, Ayumi Isaka, Akihito Ishigami, Emiko Suzuki,