کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5590091 | 1404678 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Close genetic relationships between a spousal pair with autism-affected children and high minor allele content in cases in autism-associated SNPs
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Close genetic relationships between a spousal pair with autism-affected children and high minor allele content in cases in autism-associated SNPs Close genetic relationships between a spousal pair with autism-affected children and high minor allele content in cases in autism-associated SNPs](/preview/png/5590091.png)
چکیده انگلیسی
Parents of children affected with autism spectrum disorders (ASD) often have mild forms of autistic-like characteristics. Past studies have focused on searching for individual genetic risk loci of ASD. Here we studied the overall properties of the genomes of ASD trios by using previously published genome-wide data for common SNPs. The pairwise genetic distance (PGD) between a spousal pair with ASD-affected children was found smaller than that of a random pair selected among the spouses in the ASD trios, and spousal relatedness correlated with severe forms of ASD. Furthermore, for a set of 970 ASD associated SNPs, cases showed higher homozygous minor allele content than parents. These results indicate new genetic elements in the broad phenotypes of parents with ASD-affected offspring and in ASD pathogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 109, Issue 1, January 2017, Pages 9-15
Journal: Genomics - Volume 109, Issue 1, January 2017, Pages 9-15
نویسندگان
Zuobin Zhu, Xitong Lu, Dejian Yuan, Shi Huang,