کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5590679 1570150 2017 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of IL28B genotype in the liver stiffness increase in untreated patients with chronic hepatitis C
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Role of IL28B genotype in the liver stiffness increase in untreated patients with chronic hepatitis C
چکیده انگلیسی
In the study period, 266 patients were considered. After 5 years we observed the following median stiffness increases: 6.7 kPa [5.1-7.8] in TT/CC, 4.9 kPa [4.1-5.0] in TT/TC, 3.4 kPa [3.2-3.8] in TG/TC and 1.7 kPa [1.2-1.9] in GG/TT. These values were statistically significant in all groups (p < 0.001). In the multivariate analysis resulted as predictive factors of liver stiffness progression the following: IL28B TT/CC genotype (OR = 4.571; 95%IC = 2.381-12.994; p < 0.001) and IL28B GG/TT genotype (OR = 0.510; 95%IC = 0.289-0.712; p = 0.007). In this study we evidenced that IL28B genotypes were associated with a different level of liver stiffness increase after 5 years and could be used to select the patients who should be treated with priority.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 53, September 2017, Pages 195-198
نویسندگان
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