کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5591452 | 1570395 | 2017 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia
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کلمات کلیدی
RDWMCHCHBFMCVMCHHBSpro-BNPHBSCRBCHCTSCAHBAHbA2HPFHErythrocytes - اریتروسیت هاSickle cell disease - بیماری سلول داسی شکلhereditary persistence of fetal hemoglobin - تداوم موروثی هموگلوبین جنینMean corpuscular volume - حجم متوسط مایعhealthy volunteer - داوطلب سالمelongation index - شاخص طول انقباضRed cell distribution width - عرض توزیع سلول قرمزlactate dehydrogenase - لاکتات دهیدروژناز LDH - لاکتات دهیدروژناز به صورت مختصر شده LDH Mean corpuscular hemoglobin concentration - میانگین غلظت هموگلوبین عروق کرونرhematocrit - هماتوکریتHemoglobin - هموگلوبینFetal hemoglobin - هموگلوبین جنینیHgb - هورمون رشدPascal - پاسکالSickle cell anemia - کم خونی سلولی شکمred blood cell - گلبول قرمز، اریتروسیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia](/preview/png/5591452.png)
چکیده انگلیسی
Decreased erythrocyte deformability, as measured by ektacytometry, may be associated with disease severity in sickle cell anemia (SCA). Heterogeneous populations of rigid and deformable cells in SCA blood result in distortions of diffraction pattern measurements that correlate with the concentration of hemoglobin S (HbS) and the percentage of irreversibly sickled cells. We hypothesize that red cell heterogeneity, as well as deformability, will also be influenced by the concentration of alternative hemoglobins such as fetal hemoglobin (HbF) and the adult variant, HbA2. To test this hypothesis, we investigate the relationship between diffraction pattern distortion, osmotic gradient ektacytometry parameters, and the hemoglobin composition of SCA blood. We observe a correlation between the extent of diffraction pattern distortions and percentage of HbF and HbA2. Osmotic gradient ektacytometry data indicate that minimum elongation in the hypotonic region is positively correlated with HbF, as is the osmolality at which it occurs. The osmolality at both minimum and maximum elongation is inversely correlated with HbS and HbA2. These data suggest that HbF may effectively improve surface-to-volume ratio and osmotic fragility in SCA erythrocytes. HbA2 may be relatively ineffective in improving these characteristics or cellular hydration at the levels found in this patient cohort.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Blood Cells, Molecules, and Diseases - Volume 65, June 2017, Pages 41-50
Journal: Blood Cells, Molecules, and Diseases - Volume 65, June 2017, Pages 41-50
نویسندگان
Nermi L. Parrow, Hongbin Tu, James Nichols, Pierre-Christian Violet, Corinne A. Pittman, Courtney Fitzhugh, Robert E. Fleming, Narla Mohandas, John F. Tisdale, Mark Levine,