کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5593022 | 1405057 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ãxido nÃtrico: ¿un posible nuevo biomarcador en insuficiencia cardÃaca? Relación con hipertensión pulmonar secundaria a insuficiencia cardÃaca izquierda
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Heart failure (HF) is a growing medical problem and it is of interest to study new biomarkers for better characterisation. In this sense, nitric oxide, reactive oxygen species (ROS), NADPH, and superoxide dismutase (SOD) were evaluated, along with their possible predictive value in patients with HF. An analysis was also performed on the potential differences between patients with and without secondary pulmonary hypertension (SPH), considered to have a worse prognosis. A significant decrease of nitric oxide and SOD was noted in HF, whereas ROS and NADPH were increased. These results agree with the pathophysiological changes characteristic of HF. It was also demonstrated that in patients with HF and SPH that nitric oxide and SOD were decreased when compared to HF without SPH, whereas ROS and NADPH were increased. Therefore, our results suggest that nitric oxide, ROS, NADPH, and SOD, could be considered as possible markers in HF, and could also characterise patients with SPH.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: ClÃnica e Investigación en Arteriosclerosis - Volume 29, Issue 3, MayâJune 2017, Pages 120-126
Journal: ClÃnica e Investigación en Arteriosclerosis - Volume 29, Issue 3, MayâJune 2017, Pages 120-126
نویسندگان
Roberto Jorge Bonafede, Juan Pablo Calvo, Julia MarÃa Valeria Fausti, Sonia Puebla, Adolfo Juan Gambarte, Walter Manucha,