کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5611052 | 1577873 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Coronary Flow Reserve in Idiopathic Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress, Natriuretic Peptides, and Endothelial Dysfunction
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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![عکس صفحه اول مقاله: Coronary Flow Reserve in Idiopathic Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress, Natriuretic Peptides, and Endothelial Dysfunction Coronary Flow Reserve in Idiopathic Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress, Natriuretic Peptides, and Endothelial Dysfunction](/preview/png/5611052.png)
چکیده انگلیسی
Studies have demonstrated impaired coronary blood flow reserve (CBFR) in idiopathic dilated cardiomyopathy (IDCM). It was the aim of this study to examine the potential underlying mechanisms for CBFR reduction in patients with IDCM by Doppler ultrasound techniques. Forty-eight clinically stable patients with heart failure caused by IDCM (New York Heart Association classes 1-3) were evaluated by echocardiographic and Doppler techniques with the assessments of CBFR and brachial artery flow-mediated dilation (FMD). CBFR was estimated as the hyperemic (dipyridamole: 0.84 mg/kg in 10 minutes, intravenously) to resting coronary diastolic peak velocities ratio. N-terminal pro-brain natriuretic peptide (Nt-pro-BNP) plasma levels were measured at the time of the index echocardiogram. Left ventricular (LV) ejection fraction was 30% ± 8%, and wall motion score index was 2.0 ± 0.25. The best correlation with CBFR was found with LV wall thickness-to-cavity radius (r = 0.77, P < .0001). A strong correlation of log-transformed Nt-pro-BNP levels was observed with CBFR (r = â0.64; P < .0001). No significant correlation was documented between CBFR and FMD. The stepwise regression model showed that LV wall thickness-to-cavity radius was the strongest independent predictor of CBFR followed by New York Heart Association class and log-transformed Nt-pro-BNP leading to a cumulative R value of 0.82 (P < .0001). The results of the study indicate that by measuring variables related to LV end-diastolic wall stress, such as LV wall thickness-to-cavity radius and plasma Nt-proBNP, it is possible to have information about CBFR in patients with heart failure secondary to IDCM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Echocardiography - Volume 22, Issue 4, April 2009, Pages 354-360
Journal: Journal of the American Society of Echocardiography - Volume 22, Issue 4, April 2009, Pages 354-360
نویسندگان
Frank Lloyd MD, FESC, Lorenzo MD, Umberto MD, Francesco MD, Simona MD, PhD, Stefano MD, Salvatore Mario MD,