کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622629 1406183 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleSelf-reported sleep disturbance is associated with Alzheimer's disease risk in men
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleSelf-reported sleep disturbance is associated with Alzheimer's disease risk in men
چکیده انگلیسی

ObjectiveTo study the association between self-reported sleep disturbances and dementia risk.MethodsSelf-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β-amyloid (Aβ) peptides 1-40 and 1-42 were measured at ages 70, 77, and 82 years.ResultsCox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in Aβ levels.ConclusionImproving sleep quality may help reduce the neurodegenerative risk in older men.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 9, September 2015, Pages 1090-1097
نویسندگان
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