کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622835 1406192 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleDepressive symptoms predict incident dementia during short- but not long-term follow-up period
ترجمه فارسی عنوان
علائم نشانه های مطرح شده در طول دوره کوتاه مدت، اما نه مدت طولانی، علائم زوال عقل را پیش بینی می کنند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

BackgroundWhether depression is a long-term risk factor for dementia or represents a dementia prodrome is unclear. Therefore, we examined the relationship between depressive symptoms and dementia during short and long follow-up in a population-based cohort.MethodsIn the Rotterdam Study, 4393 nondemented individuals were followed for incident dementia for 13.7 years by continuous monitoring. Cox proportional hazards models for different time intervals were used to estimate the risk of incident dementia.ResultsFive-hundred eighty-two participants developed dementia during 13.7 years. Persons with depressive symptoms had an 8% increased risk of dementia compared with those without depressive symptoms during the overall follow-up. The risk was highest in the short and intermediate follow-up, particularly in men. We did not find an association in the follow-up period beyond 10 years.ConclusionOur results suggest that late-life depressive symptoms are part of a dementia prodrome rather than an independent risk factor of dementia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 10, Issue 5, Supplement, October 2014, Pages S323-S329.e1
نویسندگان
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