کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5622839 | 1406192 | 2014 | 11 صفحه PDF | دانلود رایگان |
BackgroundTo investigate the patterns of brain atrophy, white matter (WM) tract changes, and functional connectivity (FC) abnormalities in asymptomatic granulin (GRN) mutation carriers.MethodsTen cognitively normal subjects (five mutation carriers, GRN+; years to estimated disease onset: 12 ± 7; five mutation noncarriers, GRNâ) underwent a clinical and imaging (structural, diffusion tensor, and resting-state functional magnetic resonance imaging) assessment. Brain atrophy was measured with cortical thickness analysis, WM abnormalities with tract-based spatial statistics, and FC with independent component analysis.ResultsGRN+ showed smaller cortical thickness than GRNâ in the right orbitofrontal and precentral gyrus and left rostral middle frontal gyrus. WM tracts abnormalities were limited to increased axial diffusivity in the right cingulum, superior longitudinal fasciculus, and corticospinal tract. There were no differences in FC of resting-state networks.ConclusionBrain atrophy and WM tract abnormalities in frontal-parietal circuits can be detected at least a decade before the estimated symptom onset in asymptomatic mutation carriers.
Journal: Alzheimer's & Dementia - Volume 10, Issue 5, Supplement, October 2014, Pages S354-S363.e1