کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623644 1406216 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleHippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleHippocampal thinning linked to longer TOMM40 poly-T variant lengths in the absence of the APOE ε4 variant
چکیده انگلیسی

IntroductionThe translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with apolipoprotein E (APOE), has received attention more recently as a promising gene in Alzheimer's disease (AD) risk. TOMM40 influences AD pathology through mitochondrial neurotoxicity, and the medial temporal lobe (MTL) is the most likely brain region for identifying early manifestations of AD-related morphology changes.MethodsIn this study, we examined the effects of TOMM40 using high-resolution magnetic resonance imaging in 65 healthy, older subjects with and without the APOE ε4 AD-risk variant.ResultsExamining individual subregions within the MTL, we found a significant relationship between increasing poly-T lengths of the TOMM40 variant and thickness of the entorhinal cortex only in subjects who did not carry the APOE ε4 allele.DiscussionOur data provide support for TOMM40 variant repeat length as an important contributor to AD-like MTL pathology in the absence of APOE ε4.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 7, July 2017, Pages 739-748
نویسندگان
, , , , , , , ,