کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623645 1406216 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleSmall vessel disease is linked to disrupted structural network covariance in Alzheimer's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleSmall vessel disease is linked to disrupted structural network covariance in Alzheimer's disease
چکیده انگلیسی

IntroductionCerebral small vessel disease (SVD) is thought to contribute to Alzheimer's disease (AD) through abnormalities in white matter networks. Gray matter (GM) hub covariance networks share only partial overlap with white matter connectivity, and their relationship with SVD has not been examined in AD.MethodsWe developed a multivariate analytical pipeline to elucidate the cortical GM thickness systems that covary with major network hubs and assessed whether SVD and neurodegenerative pathologic markers were associated with attenuated covariance network integrity in mild AD and normal elderly control subjects.ResultsSVD burden was associated with reduced posterior cingulate corticocortical GM network integrity and subneocorticocortical hub network integrity in AD.DiscussionThese findings provide evidence that SVD is linked to the selective disruption of cortical hub GM networks in AD brains and point to the need to consider GM hub covariance networks when assessing network disruption in mixed disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 7, July 2017, Pages 749-760
نویسندگان
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