کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623683 1406218 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleAlzheimer's disease risk variants modulate endophenotypes in mild cognitive impairment
ترجمه فارسی عنوان
انواع مختلف بیماری های آلزایمر با ویژگی های خطرناک اندوفنوتایپ ها را در اختلالات شناختی خفیف مدوله می کنند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionWe evaluated the effect of Alzheimer's disease (AD) susceptibility loci on endophenotypes closely related with AD pathology in patients with mild cognitive impairment (MCI).MethodsWe selected 1730 MCI patients from four independent data sets. Weighted polygenic risk scores (PGS) were constructed of 18 non-apolipoprotein E (APOE) AD risk variants. In addition, we determined APOE genotype. AD endophenotypes were cognitive decline over time and cerebrospinal fluid (CSF) biomarkers (aβ, tau, ptau).ResultsPGS was modestly associated with cognitive decline over time, as measured by mini-mental state examination (MMSE) (β ± SE:−0.24 ± 0.10; P = .012), and with CSF levels of tau and ptau (tau: 1.38 ± 0.36, P = 1.21 × 10−4; ptau: 1.40 ± 0.36, P = 1.02 × 10−4).DiscussionIn MCI, we observed a joint effect of AD susceptibility loci on nonamyloid endophenotypes, suggesting a link of these genetic loci with neuronal degeneration in general rather than with Alzheimer-related amyloid deposition.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 12, Issue 8, August 2016, Pages 872-881
نویسندگان
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