کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5623701 1406219 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleLower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease
ترجمه فارسی عنوان
جریان خون مغزی برجسته شده با اختلال در زمینه های مختلف شناختی در بیماری آلزایمر همراه است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی

IntroductionWe examined the association between decreased cerebral blood flow (CBF) and cognitive impairment in Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD).MethodsWe included 161 AD, 95 MCI, and 143 SCD patients from the Amsterdam Dementia Cohort. We used 3-T pseudo-continuous arterial spin labeling to estimate whole-brain and regional partial volume-corrected CBF. Neuropsychological tests covered global cognition and five cognitive domains. Associations were investigated using linear regression analyses.ResultsIn the whole sample, reduced overall and regional CBF was associated with impairment in all cognitive domains. We found significant interactions between diagnosis and CBF for language and between diagnosis and parietal CBF for global cognition and executive functioning. Stratification showed that decreased CBF was associated with worse performance in AD patients but not in MCI or SCD.DiscussionOur results suggest that CBF may have potential as a functional marker of disease severity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 13, Issue 5, May 2017, Pages 531-540
نویسندگان
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