کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5624023 1406235 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticleGlobal gray matter changes in posterior cortical atrophy: A serial imaging study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticleGlobal gray matter changes in posterior cortical atrophy: A serial imaging study
چکیده انگلیسی

BackgroundPosterior cortical atrophy (PCA) is a neurodegenerative condition predominantly associated with Alzheimer's disease (AD) pathology. Cross-sectional imaging studies have shown different atrophy patterns in PCA patients compared with typical amnestic Alzheimer's disease (tAD) patients, with greatest atrophy commonly found in posterior regions in the PCA group, whereas in the tAD group, atrophy is most prominent in medial temporal lobe regions. However, differential longitudinal atrophy patterns are not well understood.MethodsThis study assessed longitudinal changes in brain and gray matter volumes in 17 PCA patients, 16 tAD patients, and 18 healthy control subjects. Both patient groups had symptom durations of approximately 5 years.ResultsProgressive gray matter losses in both PCA and tAD patients were relatively widespread throughout the cortex, compared with control subjects, and were not confined to areas related to initial symptomatology. A multivariate classification analysis revealed a statistically significant group separation between PCA and tAD patients, with 72.7% accuracy (P < .01).ConclusionProgression from an initially focal presentation to a more global pattern suggests that these different clinical presentations of AD might converge pathologically over time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 8, Issue 6, November 2012, Pages 502-512
نویسندگان
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