کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5624261 1406242 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Featured ArticlePlasma β-amyloid 40 levels are positively associated with mortality risks in the elderly
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Featured ArticlePlasma β-amyloid 40 levels are positively associated with mortality risks in the elderly
چکیده انگلیسی

BackgroundWe evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study.MethodsAnalyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators.ResultsA relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01-1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels.ConclusionsFurther investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alzheimer's & Dementia - Volume 11, Issue 6, June 2015, Pages 672-680
نویسندگان
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