کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5627137 | 1579665 | 2017 | 5 صفحه PDF | دانلود رایگان |
- This is a study about the primary hemorrhagic neurovascular diseases in plateau area based on Chinese Tibetan patients.
- Tibetan PHNVD patients had significantly higher risk of cerebral infarction.
- Elevated hemoglobin (HGB) concentration is positively associated with the increased risk of cerebral infarction.
- Tibetan PHNVD patients are more likely to develop cerebral infarction when the HGB concentration higher than 15.2Â g/dL.
- For patients with an elevated HGB concentration, most cerebral infarctions occurred within the first five days after onset.
ObjectivesAlthough many studies have focused on primary hemorrhagic neurovascular diseases (PHNVDs) in different races, studies of PHNVDs in the plateau area of China are still insufficient. Chinese Tibetan people are the largest population living in the plateau area. Previous studies have shown that Tibetan PHNVD patients have a significantly higher incidence of cerebral infarction, but the mechanism remains uncertain. This study aimed to develop a better understanding on the mechanism of their high risk of cerebral infarction.Patients and methodsIn this retrospective case control study, we used a hospital information system to search for consecutive Tibetan patients with PHNVDs from January 2012 to June 2016. Intra-hospital data including baseline information and complications were recorded, and the risk factors for cerebral infarction were analyzed.ResultsUnivariate analysis and cox proportional hazard multivariate regression analysis revealed that elevated hemoglobin (HGB) concentration was positively associated with an increased incidence of cerebral infarction (PÂ <Â 0.001). The cutoff value that maximized the ability to predict in-hospital infarction in Tibetans with PHNVDs was 15.2Â g/dL. Tibetan PHNVD patients with an increased HGB concentration were more likely to present with cerebral infarction within the first 5Â days after onset of PHNVDs, and the probability was highest on the 3rd day.ConclusionsHGB levels could be used to predict in-hospital cerebral infarction in Tibetan patients with PHNVDs. These patients are more likely to develop in-hospital infarction when the HGB concentration is higher than 15.2Â g/dL. For Tibetan PHNVD patients with an elevated HGB concentration, most cerebral infarctions occurred within the first five days after onset, with more incidents occurring on the third day.
Journal: Clinical Neurology and Neurosurgery - Volume 157, June 2017, Pages 46-50