کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627990 1579822 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The current status of artisanal cannabis for the treatment of epilepsy in the United States
ترجمه فارسی عنوان
وضعیت کنونی شاهدانه بومی برای درمان صرع در ایالات متحده
کلمات کلیدی
شاهزاده خانمها، کانابینوئید، صرع، کانابیدیول، اسید تتراهیدروکانیکوبولیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy.
- 86% of 272 patients with refractory epilepsy experienced some benefit from the use of artisanal cannabis preparations.
- Cannabis preparations caused increased seizures in 4% of patients; other adverse effects were mild and well tolerated.
- Effective total cannabinoid doses ranged from 0.05 to 9 mg/kg/day; effective serum levels of CBD ranged from 1.8 to 80 ng/ml.
- Despite the inherent clinical challenges, patients with refractory epilepsy may benefit from artisanal cannabis preparations.

The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. We report the retrospective data on efficacy and adverse effects of artisanal cannabis in Patients with medically refractory epilepsy with mixed etiologies in Washington State, California, and Maine. Clinical considerations, including potential risks and benefits, challenges related to artisanal preparations, and cannabinoid dosing, are discussed.ResultsOf 272 combined patients from Washington State and California, 37 (14%) found cannabis ineffective at reducing seizures, 29 (15%) experienced a 1-25% reduction in seizures, 60 (18%) experienced a 26-50% reduction in seizures, 45 (17%) experienced a 51-75% reduction in seizures, 75 (28%) experienced a 76-99% reduction in seizures, and 26 (10%) experienced a complete clinical response. Overall, adverse effects were mild and infrequent, and beneficial side effects such as increased alertness were reported. The majority of patients used cannabidiol (CBD)-enriched artisanal formulas, some with the addition of delta-9-tetrahydrocannabinol (THC) and tetrahydrocannabinolic acid (THCA). Four case reports are included that illustrate clinical responses at doses < 0.1 mg/kg/day, biphasic dose-response effects, the use of THCA for seizure prevention, the use of THC for seizure rescue, and the synergy of cannabinoids and terpenoids in artisanal preparations.This article is part of a Special Issue entitled "Cannabinoids and Epilepsy".

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 70, Part B, May 2017, Pages 328-333
نویسندگان
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