Review ArticleRespiratory neuroplasticity - Overview, significance and future directions

- Neuroplasticity is an important property of the respiratory neural control system.
- Respiratory neuroplasticity can improve motor function in neuromuscular disease.
- We review the biological and clinical significance of respiratory neuroplasticity.
- Respiratory neuroplasticity topics in need of future research effort are identified.

Neuroplasticity is an important property of the neural system controlling breathing. However, our appreciation for its importance is still relatively new, and we have much to learn concerning different forms of plasticity, their underlying mechanisms, and their biological and clinical significance. In this brief review, we discuss several well-studied models of respiratory plasticity, including plasticity initiated by inactivity in the respiratory system, intermittent and sustained hypoxia, and traumatic injury to the spinal cord. Other aspects of respiratory plasticity are considered in other contributions to this special edition of Experimental Neurology on respiratory plasticity. Finally, we conclude with discussions concerning the biological and clinical significance of respiratory motor plasticity, and areas in need of future research effort.