کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5638001 1583273 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Response of mandibular condyles of juvenile and adult rats to abnormal occlusion and subsequent exemption
ترجمه فارسی عنوان
پاسخ کاندیدیهای فک پایین فک پایین موشهای نوجوان و بالغ به انسداد غیر طبیعی و معافیت پس از آن
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


- Response of mandibular condyles to abnormal occlusion differed between juvenile and adult rats.
- Abnormal molar occlusion led to degenerative remodeling in the mandibular condyles of both juvenile and adult rats
- Exemption of malocclusion caused significant rescue of the degenerative changes only in juvenile rats.

ObjectiveThe adaptation capacities of the mandibular condyle in response to mechanical stimuli might be different between juveniles and adults, but has not been compared. This study aimed to investigate whether abnormal molar occlusion and subsequent molar extraction could lead to different remodeling responses in the mandibular condyles of juvenile and adult rats.MethodsAbnormal molar occlusion (AMO) was established in the 5- and 16-wk old rats by moving their maxillary left and mandibular right third molars distally. AMO was removed in the molar extraction group at 4 weeks but remained in the AMO group. All rats were sacrificed at 8 weeks. Micro-computed tomography, histomorphology, immunohistochemistry and real-time PCR were adopted to evaluate the remodeling of condylar subchondral bone.ResultsCondylar subchondral bone loss and increased osteoclastic activities were observed in both juvenile and adult AMO groups, while increased osteoblastic activities were only seen in the juvenile AMO group. Decreased bone mineral density, bone volume fraction and trabecular thickness, but increased trabecular separation, number and surface of osteoclasts and mRNA levels of TRAP, cathepsin-K, RANKL in the juvenile AMO group were all reversed after molar extraction (all P < 0.05). However, these parameters showed no difference between adult AMO and extraction groups (all P > 0.05).ConclusionsAbnormal molar occlusion led to degenerative remodeling in the mandibular condyles of both juvenile and adult rats, while exemption of abnormal occlusion caused significant rescue of the degenerative changes only in the juvenile rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 80, August 2017, Pages 136-143
نویسندگان
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