RNA isolation from alveolar bone and gene expression analysis of RANK, RANKL and OPG: A new tool to monitor bone remodeling and healing in different bone substitutes used for prosthetic rehabilitation

The alveolar site grafted with a granular biomaterial behaved similar to the physiological healing group but displayed a slow remodeling process. RANK, RANKL, OPG and the RANKL/OPG ratio might be able to distinguish among different biomaterials and represent different healing patterns according to different clinical conditions.