کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5638061 1583274 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The local administration of parathyroid hormone encourages the healing of bone defects in the rat calvaria: Micro-computed tomography, histological and histomorphometric evaluation
ترجمه فارسی عنوان
اداره محلی هورمون پاراتیرویید، بهبودی نقایص استخوانی را در کلورویا موشی تشویق می کند: توموگرافی کامپیوتری، ارزیابی بافتی و هیستومورفومتریک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی


- The local administration of PTH on bone healing in rat bone defects was evaluated.
- Micro-CT, histological and histomorphometric analysis were performed.
- At 15 days post-surgery, PTH Group exhibited higher percentage of bone formation.
- The results suggest that PTH encouraged the initial bone healing in bone defects.

ObjectiveTo evaluate the effect of a single-dose local administration of PTH on bone healing in rat calvarial bone defects by means of micro-computed tomography, histological and histomorphometric analysis.DesignCritical-size cranial osteotomy defects were created in 42 male rats. The animals were randomly divided into 3 groups. In the C Group, the bone defect was only filled with a blood clot. In the S Group, it was filled with a collagen sponge and covered with bovine cortical membrane. In the PTH Group, the defect was filled with a collagen sponge soaked with PTH and covered with bovine cortical membrane. The groups were further split in two for euthanasia 15 and 60 days post-surgery. Data was statistically analyzed with t-tests for independent samples or the nonparametric Mann-Whitney test when applicable. Intragroup comparisons were analyzed with paired t-tests (p < 0.05).ResultsMicro-CT analysis results did not demonstrate statistically significant intergroup differences. At 15 days post-surgery, the histomorphometric analysis showed that the PTH Group exhibited a significantly higher percentage of bone formation compared with the S Group. At 60 days post-surgery, a higher percentage of new bone was observed in the PTH group.ConclusionThe results suggest that the local administration of PTH encouraged the bone healing in critical-size calvarial defects in rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 79, July 2017, Pages 14-19
نویسندگان
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