Fluoride concentration and amount of dentifrice influence enamel demineralization in situ

The treatment intensity has a significant influence on the development of caries lesions in situ. Clinical significance: The intensity of treatment (amount of dentifrice × concentration) during brushing seems to be a more relevant parameter of clinical efficacy than simply observing the F concentration of the product. The use of a small amount of CD significantly reduced the protective effects against enamel demineralization.