کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5654812 1589407 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients
چکیده انگلیسی


- Melanoma tumors are more aggressive when expressing high levels of HLA-ABC and HLA-G.
- HLA-G expression is correlated with a high number of FOXP3+ lymphocytes in the tumor.
- High HLA-ABC expression is associated with bad prognostic factors.

HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P < 0.001), frequent ulceration (20% vs 6%, P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P < 0.001) and positive sentinel node (13% vs 6%, P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 183, October 2017, Pages 191-197
نویسندگان
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