کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5654930 | 1589414 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
GAD-specific T cells are induced by GAD-alum treatment in Type-1 diabetes patients
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کلمات کلیدی
T1DPBMCTregTMRglutamic acid decarboxylase 65GADGAD65PBSBSA - BSAbovine serum albumin - آلبومین سرم گاوinterleukin - اینترلوکینtetramer - تترامرTeff - تیفType 1 diabetes - دیابت نوع۱effector T cell - سلول T effectorRegulatory T cell - سلول T تنظیم کنندهPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیRegulatory T cells - سلولهای تی تنظیمکنندهPhosphate buffered saline - فسفات بافر شورImmune intervention - مداخلات ایمنیChildren - کودکان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Administration of Glutamic Acid Decarboxylase (GAD)65 formulated in aluminium hydroxide preserved insulin secretion in a phase II trial in recent onset Type 1 Diabetes. A subsequent European phase III trial was closed at 15Â months after failing to reach primary endpoint, but the majority of the Swedish patients completed the 21Â months follow-up. We studied the frequencies and phenotype of T cells, suppressive capacity of Tregs, GAD65-induced proliferation, and frequencies of T cells with a GAD65-specific TCR in Swedes participating in the trial. Stimulation with GAD65 induced activated T cells and also cells with a suppressive phenotype. Activated GAD65-specific effector T cells were detected by tetramer staining while the frequency of GAD65-specific Treg was not affected by the treatment. Additional doses of GAD-alum increased frequencies of CD25+Â CD127+, but had no effect on CD25hiCD127lo. Our findings indicate that GAD-alum treatment primarily induced activated T cells. GAD65-specific cells were mainly of activated phenotype.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 176, March 2017, Pages 114-121
Journal: Clinical Immunology - Volume 176, March 2017, Pages 114-121
نویسندگان
Mikael Pihl, Hugo Barcenilla, Stina Axelsson, Mikael Chéramy, Linda Ã
kerman, Ingela Johansson, Johnny Ludvigsson, Rosaura Casas,