کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5654939 | 1589415 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plasmacytoid dendritic cell distribution and maturation are altered in lupus prone mice prior to the onset of clinical disease
ترجمه فارسی عنوان
توزیع و بلوغ سلول های دندریتیک پلاسمایی در موش های مبتلا به لوپوس قبل از شروع بیماری بالینی
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کلمات کلیدی
TLRNZMLDCERαMDCPDCCDCinterferon - اینترفرونIFN - اینترفرون هاToll-like receptor - تیالآرRodent - جوندگانautoimmunity - خودایمنیDendritic cell - سلول دندریتیکPlasmacytoid dendritic cell - سلول دندریتیک پلاسماییکوئیدDendritic cells - سلول های دندریتیکMyeloid dendritic cell - سلول های دندریتیک میلوئیدSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکbone marrow - مغز استخوانwild-type - نوع وحشیEstrogen receptor alpha - گیرنده استروژن آلفا
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Plasmacytoid dendritic cells (pDCs) and their production of type I interferons (IFN) are key pathogenic mediators of systemic lupus erythematosus (SLE). Despite the key role of pDCs in SLE, the mechanism by which pDCs promote disease is not well understood. The first objective for this study was to assess the number and maturation state of pDCs in pre-disease NZM2410 lupus prone mice compared to control mice. Second, we sought to identify mechanisms responsible for the alteration in pDCs in NZM mice prior to onset of clinical disease. We compared the number and percent of pDCs in the spleens and bone marrow (BM) of pre-disease NZM24010 (NZM) mice to C57BL/6 (B6) control mice. In the spleens of pre-disease NZM mice, pDC percent and number were increased. This increase occurs in parallel with a decrease in BM pDC number and percent in the NZM mice. The decrease in BM pDC number suggests the increase in spleen pDCs is a result of altered pDC distribution and not increased production of pDCs in the BM. To determine if pDC developmental potential is altered in lupus prone mice, we cultured BM from NZM and B6 mice in vitro. We found a reduced percentage/number of pDCs developing from the BM of NZM mice compared to B6 mice, which further supports that the increase in pDC number is a result of altered pDC distribution rather than increased pDC production. To better characterize the pDC population, we compared the percentage of mature pDCs in the spleens and BM of NZM mice to controls. In the NZM mice, there is a dramatic reduction in the number of mature pDCs in the BM of NZM mice, suggesting that mature pDCs exit the BM at a higher rate/earlier maturation time compared to healthy mice. We conclude that pDCs contribution to disease pathogenesis in NZM mice may include the alteration of pDC distribution to increase the number of pDCs in the spleen prior to disease onset.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 175, February 2017, Pages 109-114
Journal: Clinical Immunology - Volume 175, February 2017, Pages 109-114
نویسندگان
Jennifer L. Scott, Jena R. Wirth, Jackie G. EuDaly, Gary S. Gilkeson, Melissa A. Cunningham,