کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5664116 1590701 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients' outcome
ترجمه فارسی عنوان
متاستازهای مغز از کارسینوم سلول های غیر سلولی کوچک: تغییر مفاهیم برای بهبود نتیجه بیماران
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

The management of Non Small Cell Lung Cancer (NSCLC) brain metastases is challenging, as this frequent complication negatively impacts patients' quality of life, and can be a life-threatening event.Through a review of the literature, we discuss the main therapeutic options and the recent developments that improved (and complicated) the management of NSCLC brain metastases patients. Most current validated approaches are local with exclusive or combined surgery, whole brain radiotherapy (WBRT) and stereotactic radiotherapy (SRT). At the same time, there is a growing role for systemic treatments that might significantly postpone WBRT. Targeted therapies efficacy/toxicity profile remains to be defined but predictive and prognostic molecular factors integration could help to select treatments fully adapted to life expectancy and progression risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 116, August 2017, Pages 32-37
نویسندگان
, , , , , , ,