Hepatitis E virus: Emerging from the shadows in developed countries

Following the discovery of HEV in the 1980s, it became apparent that HEV is endemic in a number of developing countries in Asia, Africa and Mexico. In these geographical settings HEV is spread oral faecally by HEV genotypes (gt) 1 and 2, which are obligate human pathogens. Infection occurs oro-faecally, often as a result in the breakdown of fragile sanitary infrastructure allowing drinking water supplies to become contaminated with human sewage. Hepatitis E usually causes a self-limiting hepatitis in young adults with sporadic cases and occasional dramatic outbreaks involving hundreds or thousands of cases. Clinically the illness is indistinguishable from hepatitis A, except in pregnant women where the mortality is 20-25%. Death occurs in the third trimester from fulminant hepatic failure and obstetric complications such as eclampsia, with very high associated foetal loss. For the best part of 20 years hepatitis E was considered as an imported disease in developed countries, and was only seen in travellers returning from endemic developing countries. We got this very badly wrong: HEV gt3 was 'hiding in the shadows' in humans, pigs, and other animals.