کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5665673 1591293 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy
ترجمه فارسی عنوان
مکانیزم های رمان در تحمل ایمنی به آلرژن ها در هنگام قرار گرفتن در معرض آلرژن طبیعی و ایمنوتراپی خاص با آلرژن خاص
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Allergen-specific immunotherapy is effective in reducing symptoms of allergic asthma and rhinitis as well as venom-allergy with the possibility of clinical cure.
- Multiple mechanisms and receptors play a role in allergen tolerance, such as IL-10, TGF-β, histamine receptor 2, PD-1 and CTLA-4.
- Recently, roles for innate lymphoid cells have been demonstrated in allergy development and allergen tolerance.
- Similar cellular and molecular mechanisms are apparently utilized in prevention of allergic disease.

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a clinical tolerance-inducing and immune tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms including early desensitization of basophils and mast cells, regulating T-cell and B-cell responses, changing antibody isotypes, and decreasing activation, mediator release and affected tissue migration of eosinophils, basophils, and mast cells. Similar molecular and cellular mechanisms have been observed in subcutaneous AIT, sublingual AIT and peptide immunotherapy as well as natural tolerance to high doses of allergen exposure in beekeepers and cat owners.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 48, October 2017, Pages 74-81
نویسندگان
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