Novel immunologic mechanisms in eosinophilic esophagitis

- Eosinophilic esophagitis (EoE) is a tissue-specific disease.
- EoE epithelium exhibits impaired barrier function and dysregulated differentiation.
- Innate and adaptive immunologic mechanisms drive EoE pathogenesis.
- Both genetic and environmental components influence EoE pathogenesis.
- Recently developed rational EoE therapies reduce esophageal eosinophilia.