کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5666571 | 1591536 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway](/preview/png/5666571.png)
- Autoimmune hepatitis model have liver injury and upper small intestine villi disruption.
- Sodium butyrate exerts protective effect on liver and upper small intestine.
- Dietary advice on the patience of autoimmune hepatitis.
Background and aimRecent investigation revealed that dysbiosis in the gut flora and disruption of permeability of intestinal barrier are possible causes for the development of autoimmune hepatitis. Supplementation of sodium butyrate has been suggested to protect liver injury from disrupted permeability of small intestine. In current study, we employed S100/Freund's complete adjuvant induced autoimmune hepatitis to investigate therapeutic efficacy of sodium butyrate and its mechanism in the liver and upper small intestine.MethodsC57BL/6 mice were employed and divided into three groups - control group (n = 8), autoimmune hepatitis group (n = 12) and autoimmune hepatitis with treatment of sodium butyrate group (n = 12). Histological staining and western blot analyses were employed to evaluate liver and upper small intestine morphology and gene expression respectively.ResultsThe findings revealed that S100/Freund's complete adjuvant caused liver injury and disruption of upper small intestine villi. Sodium butyrate attenuated the injuries and prevented migration of Escherichia coli into the liver. Moreover, the effect of sodium butyrate on protection of injuries of the liver and upper small intestine could be due to inhibition of toll-like receptor 4 signaling pathway, as well as its down-regulation of inflammatory cytokines - interleukin-6 and tumor necrosis factor-a.ConclusionsSodium butyrate can prevent liver injury by maintaining the integrity of small intestine and inhibiting inflammatory response in S100/Freund's complete adjuvant induced autoimmune hepatitis.
Journal: Immunology Letters - Volume 190, October 2017, Pages 169-176