Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells

- Designs of CAR construct elements are proposed in the text.
- Different types of toxicity phenomenon and their corresponding solutions.
- Some helpful prevention measures are also provided.
- Managing toxicity is quite urgent for chimeric antigen receptor (CAR) modified T cells treatment.

Adoptive immunotherapy adopting chimeric antigen receptor (CAR) modified T cells has arisen attention as a hard-hitting therapy for numerous cancers. CARs are genetically engineered receptors that could stimulate tumor cytotoxicity once binding to the specific tumor epitopes. In spite of current noteworthy achievements in hematologic malignancies, the safety problems have aroused public awareness. In this review, we will focus on recent potential strategies to improve the security of CAR modified T cells.