کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666629 1591547 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Yin and Yang of Innate Lymphoid Cells in Cancer
ترجمه فارسی عنوان
یین و یانگ سلولهای لنفوئیدی در سرطان
کلمات کلیدی
سرطان، سلول های لنفی عظیم، سیتوکین ها، اینترفرون-γ، اینترلوکین 22، ساختارهای لنفاوی ترشحات،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- The involvement of ILC subsets in tumor immunity has been barely investigated.
- ILCs might behave either as friends or foes in cancer.
- ILCs are an early source of cytokines able to affect tumor microenvironment.
- Anti- or pro-tumorigenic functions of ILCs depend on the context of tumor specificity.

The recent appreciation of novel subsets of innate lymphoid cells (ILCs) as important regulators of tissue homeostasis, inflammation and repair, raise questions regarding the presence and role of these cells in cancer tissues. In addition to natural killer and fetal lymphoid tissue inducer (LTi) cells, the ILC family comprises non-cytolytic, cytokine-producing cells that are classified into ILC1, ILC2 and ILC3 based on phenotypic and functional characteristics.Differently from natural killer cells, which are the prototypical members of ILC1 and whose role in tumors is better established, the involvement of other ILC subsets in cancer progression or resistance is still fuzzy and in several instances controversial, since current studies indicate both context-dependent beneficial or pathogenic effects.Here, we review the current knowledge regarding the involvement of these novel ILC subsets in the context of tumor immunology, highlighting how ILC subsets might behave either as friends or foes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 179, November 2016, Pages 29-35
نویسندگان
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