کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666663 1591537 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recombinant allergy vaccines based on allergen-derived B cell epitopes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Recombinant allergy vaccines based on allergen-derived B cell epitopes
چکیده انگلیسی


- More than 25% of population suffers from IgE-associated allergy.
- Allergen-specific immunotherapy is the only disease-modifying allergy treatment.
- Recombinant allergy vaccines based on allergen-derived B cell epitopes hold promise to revolutionize therapeutic allergy vaccination.
- B cell epitope-based allergy vaccines may be suitable for prophylactic allergy vaccination.

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensitivity disease. It affects more than 25% of the population. In IgE-sensitized subjects, allergen encounter can causes a variety of symptoms ranging from hayfever (allergic rhinoconjunctivitis) to asthma, skin inflammation, food allergy and severe life-threatening anaphylactic shock. Allergen-specific immunotherapy (AIT) is based on vaccination with the disease-causing allergens. AIT is an extremely effective, causative and disease-modifying treatment. However, administration of natural allergens can cause severe side effects and the quality of natural allergen extracts limits its application. Research in the field of molecular allergen characterization has allowed deciphering the molecular structures of the disease-causing allergens and it has become possible to engineer novel molecular allergy vaccines which precisely target the mechanisms of the allergic immune response and even appear suitable for prophylactic allergy vaccination. Here we discuss recombinant allergy vaccines which are based on allergen-derived B cell epitopes regarding their molecular and immunological properties and review the results obtained in clinical studies with this new type of allergy vaccines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 189, September 2017, Pages 19-26
نویسندگان
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