کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666717 1591538 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lymphocyte subsets are influenced by positivity levels in healthy subjects before and after mild acute stress
ترجمه فارسی عنوان
زیرمجموعه های لنفوسیت تحت تأثیر سطوح مثبت در افراد سالم قبل و بعد از استرس حاد خفیف قرار می گیرند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Positivity is a psychological asset to view life under positive outlook.
- Lymphocyte subsets are influenced by positivity levels.
- Immune system of high positivity subjects seems to better respond to stress.

In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed.Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acute stress test, in 41 healthy students, previously selected by a questionnaire for their level of POS (high [POS-H] and low [POS-L]).The CD3+ and CD4+ cell frequency was higher in the POS-H students before and after acute stress. CD4+ subpopulation analysis revealed baseline higher terminally differentiated frequency in the POS-H, whereas higher effector memory frequency was present in the POS-L students. Moreover, the frequency of post-stress B cells was higher in the POS-H students.The mild-stress test was associated to an increase of the IL-10 mean values, while mean values of the other cytokines tested did not change significantly.It is tempting to speculate that IL-10 may work as biomarker of response to acute mild stress and that POS-H may be associated to a better capacity of the immune system to contrast the disturbing effects of mild acute stress. Yet further studies on lymphocyte subset absolute number and function of larger and different populations are needed to definitively prove these preliminary observations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 188, August 2017, Pages 13-20
نویسندگان
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