کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5666730 | 1591538 | 2017 | 8 صفحه PDF | دانلود رایگان |

- Myeloid-derived suppressor cells (MDSCs) are important mediators of the immune cells.
- MDSCs impair B-cell proliferation and induce B-cell death.
- MDSCs decrease B-cell IgM responses and down regulate the expression of important ctivation surface markers.
- MDSCs use of reactive oxygen species (ROS), arginase-1, and nitric oxide (NO) to modulate B-cell immune responses.
Myeloid-derived suppressor cells (MDSCs) are key regulators of adaptive immunity by suppressing T-cell functions. However, their potential action on or interaction with B cells remained poorly understood. Here we demonstrate that human polymorphonuclear MDSCs differentially modulate B-cell function by suppressing B-cell proliferation and antibody production. We further demonstrate that this MDSC-mediated effect is cell contact dependent and involves established mediators such as arginase-1, nitric oxide (NO), reactive oxygen species (ROS) as well as B-cell death. Collectively, our studies provide novel evidence that human MDSCs modulate B cells, which could have future implications for immunotherapy approaches.
Journal: Immunology Letters - Volume 188, August 2017, Pages 108-115