کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5673609 1593678 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunization with recombinant GntR plasmid confers protection against Brucella challenge in BALB/c mice
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Immunization with recombinant GntR plasmid confers protection against Brucella challenge in BALB/c mice
چکیده انگلیسی


- The pVGntR DNA vaccine can elicit IgG response.
- The pVGntR DNA vaccine induces cellular responses.
- The pVGntR DNA vaccine induces protection against B. abortus challenge.

It is essential to improve animal vaccine for brucellosis since conventional vaccines are residual virulent and poor protective effect, limit their applications. To solve these problems, the recombinant DNA vaccines were appeared, which could improve protective immunity and were attenuated to animals. In current research, the recombinant DNA vaccine (pVGntR) based on transcriptional regulator GntR of Brucella abortus (B. abortus) was constructed. The results show that pVGntR is significantly more protective than the conventional RB51 vaccine. Immunization with pVGntR increases the production of immunoglobulin G (IgG) and elicits elevated numbers of gamma interferon (IFN-γ) and interleukin-4 (IL-4). These results suggest that pVGntR is a highly efficacious vaccine candidate that confers protection against wild-type B. abortus challenge.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 111, October 2017, Pages 357-361
نویسندگان
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