کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5673736 1408207 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Neutralizing antichlamydial activity of complement by chlamydia-secreted protease CPAF
چکیده انگلیسی
Ascending infection by sexually transmitted Chlamydia trachomatis is required for chlamydial induction of tubal pathology. To achieve ascension, the C. trachomatis organisms may have to spread from cell to cell, which inevitably exposes the organisms to extracellular mucosal effectors such as complement factors that are known to possess strong antichlamydial activities. Here, we report that the chlamydia-secreted protease CPAF efficiently neutralized complement factor C3-dependent antichlamydial activity. The neutralization was dependent on the proteolytic activity of CPAF and correlated with the CPAF-mediated degradation of complement factor C3 and factor B. As a result, CPAF preferentially inhibited the alternative complement activation pathway. The significance and limitation of these observations were discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 18, Issue 11, November 2016, Pages 669-674
نویسندگان
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