کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5674861 1594205 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibition of the lytic cycle of Kaposi's sarcoma-associated herpesvirus by cohesin factors following de novo infection
ترجمه فارسی عنوان
مهار چرخه ی لیتیک یکی از تبخال های ویروسی با سارکوم کاپوزی به وسیله یک عوامل کوهنس پس از ابتلا به دیو نوو
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- CTCF and cohesin rapidly bind to the KSHV DNA during de novo infection.
- KSHV can replicate in cohesin-depleted cells following infection.
- Cohesin is required for the establishment of KSHV latency.

Establishment of Kaposi's sarcoma-associated herpesvirus (KSHV) latency following infection is a multistep process, during which polycomb proteins are recruited onto the KSHV genome, which is crucial for the genome-wide repression of lytic genes during latency. Strikingly, only a subset of lytic genes are expressed transiently in the early phase of infection prior to the binding of polycomb proteins onto the KSHV genome, which raises the question what restricts lytic gene expression in the first hours of infection. Here, we demonstrate that both CTCF and cohesin chromatin organizing factors are rapidly recruited to the viral genome prior to the binding of polycombs during de novo infection, but only cohesin is required for the genome-wide inhibition of lytic genes. We propose that cohesin is required for the establishment of KSHV latency by initiating the repression of lytic genes following infection, which is an essential step in persistent infection of humans.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 512, December 2017, Pages 25-33
نویسندگان
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