کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5675432 1594329 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Competitive replication kinetics and pathogenicity in pigs co-infected with historical and newly invading classical swine fever viruses
ترجمه فارسی عنوان
سینتیک تکراری رقابت پذیر و پاتوژنز در خوک های آلوده به ویروس های قدیمی کبد تاریخی و اخیرا مهاجم
کلمات کلیدی
ویروس کبد خوک ژنوتیپ، تغییر ویروس، تکرار ویروسی، پاتوژنز،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی
Classical swine fever (CSF), an economically important and highly contagious disease of pigs, is caused by classical swine fever virus (CSFV). In Taiwan, CSFVs from field outbreaks belong to two distinct genotypes. The historical genotype 3.4 dominated from the 1920s to 1996, and since 1996, the newly invading genotype 2.1 has dominated. To explain the phenomenon of this virus shift in the field, representative viruses belonging to genotypes 2.1 and 3.4 were either inoculated alone (single infection) or co-inoculated (co-infection), both in vivo and in vitro, to compare the virus replication and pathogenesis. In pigs co-infected with the genotype 2.1 TD/96/TWN strain and the genotype 3.4 94.4/IL/94/TWN strain, the newly invading genotype 2.1 was detected earlier in the blood, oral fluid, and feces, and the viral loads were consistently and significantly higher than that of the historical genotype 3.4. In cell cultures, the ratio of secreted virus to cell-associated virus of the genotype 2.1 strain was higher than that of the genotype 3.4 strain. This study is the first to demonstrate a possible explanation of virus shift in the field, wherein the newly invading genotype 2.1 replicates more efficiently than did genotype 3.4 and outcompetes the replication and pathogenicity of genotype 3.4 in pigs in the field.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virus Research - Volume 228, 15 January 2017, Pages 39-45
نویسندگان
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