کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5682448 1597723 2017 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiological considerations acting on triplet oxygen for explicit dosimetry in photodynamic therapy
ترجمه فارسی عنوان
ملاحظات فیزیولوژیکی بر اکسیژن سه گانه که برای دوزیمتری صریح در درمان فوتودینامیک عمل می کنند
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
The aims of this study were to determine the spatial and temporal theoretical distribution of the concentrations of Protoporphyrin IX, 3O2 and doses of 1O2. The type II mechanism and explicit dosimetry in photodynamic therapy were used. Furthermore, the mechanism of respiration and cellular metabolism acting on 3O2 were taken into account. The dermis was considered as an absorbing and a scattering medium. An analytical solution was used for light diffusion in the skin. The photophysical, photochemical and biological effects caused by PDT with the initial irradiances of 20, 60 and 150 mW/cm2 were studied for a time of exposure of 20 min and a maximum depth of 0.5 cm. We found that the initial irradiance triples its value in 0.02 cm and that almost 100% of PpIX is part of the dynamics of reactions in photodynamic therapy. Additionally, with about 40 μM of 3O2 there is a balance between the consumed and supplied oxygen. Finally, we determined that with 60 mW/cm2, the highest dose of 1O2 is obtained.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Photodiagnosis and Photodynamic Therapy - Volume 19, September 2017, Pages 298-303
نویسندگان
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