Management of elderly patients with early-stage medically inoperable endometrial cancer: Systematic review and National Cancer Database analysis

The available evidence suggests high rates of local control after radiation therapy for elderly women with Stage I-II medically inoperable endometrial cancer. Our analysis of the NCDB suggests that radiation therapy improves survival, and combination therapy provides the most favorable outcomes. Given a relatively favorable toxicity profile, definitive radiation therapy should be considered a preferred approach for patients with medically inoperable endometrial cancer.