کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5697447 | 1410307 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Les 50Â ans du cisplatine
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
تومور شناسی
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چکیده انگلیسی
We have just celebrated the 50th anniversary of cisplatin cytotoxic potential discovery. It is time to take stock⦠and it seems mainly positive. This drug, that revolutionized the treatment of many cancer types, continues to be the most widely prescribed chemotherapy. Despite significant toxicities, resistance mechanisms associated with treatment failures, and unresolved questions about its mechanism of action, the use of this cytotoxic agent remains unwavering. The interest concerning this “old” invincible drug has not yet abated. Indeed many research axes are in the news. New platinum salts agents are tested, new cisplatin formulations are developed to target tumor cells more efficiently, and new combinations are established to increase the cytotoxic potency of cisplatin or overcome the resistance mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bulletin du Cancer - Volume 104, Issue 2, February 2017, Pages 167-176
Journal: Bulletin du Cancer - Volume 104, Issue 2, February 2017, Pages 167-176
نویسندگان
Chloé Rancoule, Jean-Baptiste Guy, Alexis Vallard, Majed Ben Mrad, Amel Rehailia, Nicolas Magné,