کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5698049 1410338 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Modulating the DNA Damage Response to Improve Treatment Response in Cervical Cancer
چکیده انگلیسی
Cervical cancer is the fourth most common cause of cancer-related death in women worldwide and new therapeutic approaches are needed to improve clinical outcomes for this group of patients. Current treatment protocols for locally advanced and metastatic disease consist of ionising radiation and chemotherapy. Chemoradiation induces cytotoxic levels of DNA double-strand breaks, which activates programmed cell death via the DNA damage response (DDR). Cervical cancers are unique given an almost exclusive association with human papillomavirus (HPV) infection; a potent manipulator of the DDR, with the potential to alter tumour sensitivity to DNA-damaging agents and influence treatment response. This review highlights the wide range of therapeutic strategies in development that have the potential to modulate DDR and sensitise cervical tumours to DNA-damaging agents in the context of HPV oncogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Oncology - Volume 29, Issue 9, September 2017, Pages 626-634
نویسندگان
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