The Prognostic Significance of the Biomarker p16 in Oropharyngeal Squamous Cell Carcinoma

This study shows that p16 is the single most important prognostic variable in OPSCC, surpassing traditional prognostic factors for both CSS and RFS. Furthermore, disease stage has no prognostic significance in p16-positive patients, highlighting the need for routine p16 assessment in OPSCC.