Target Volume Definition for Intensity-modulated Radiotherapy after Induction Chemotherapy and Patterns of Treatment Failure after Sequential Chemoradiotherapy in Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma

The absence of marginal recurrences validated the approach to IMRT target volume definition after induction chemotherapy proposed by clinical practice guidelines and practised at our institution. It suggested a lack of benefit with the use of larger geometric margins and additional anatomical expansion for the high-dose clinical target volume. SCRT resulted in excellent regional and distant disease control in patients with locoregionally advanced oropharyngeal SCC.