کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5699043 1410393 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Beyond Prostate-specific Antigen - Future Biomarkers for the Early Detection and Management of Prostate Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Beyond Prostate-specific Antigen - Future Biomarkers for the Early Detection and Management of Prostate Cancer
چکیده انگلیسی
Prostate-specific antigen is currently commonly used as a screening biomarker for prostate cancer, but it has limitations in both sensitivity and specificity. The development of novel biomarkers for early cancer detection has the potential to improve survival, reduce unnecessary investigations and benefit the health economy. Here we review the use and limitations of prostate-specific antigen and its subtypes, urinary biomarkers including PCA3, alpha-methylacyl-CoA racemase, the TMPRSS2-ERG fusion gene and microseminoprotein-beta, and other novel markers in both serum and urine. Many of these biomarkers are at early stages of development and require evaluation in prospective trials to determine their potential usefulness in clinical practice. Genetic profiling may allow for the targeting of high-risk populations for screening and may offer the opportunity to combine biomarker results with genotype to aid risk assessment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Oncology - Volume 24, Issue 8, October 2012, Pages 545-555
نویسندگان
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