کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5723562 | 1609056 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differences between Metabolically Healthy vs Unhealthy Obese Children and Adolescents
ترجمه فارسی عنوان
تفاوت بین کودکان و نوجوانان متابولیک سالم در مقابل بیماری های نارسایی چاقی
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کلمات کلیدی
چاقی، سالم متابولیک، متابولیک ناسالم فرزندان، نوجوانان،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی
Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. We aimed to identify MHO and metabolically unhealthy obese (MUO) children and adolescents with respect to metabolic factors, and to find predictors of MHO subtype. A retrospective chart review was done on children, ages 4-19 years, 99% African-American/Caribbean, with BMI â¥95th %tile. MUO was defined as meeting â¥1 of the following: fasting glucose â¥100 mg/dl, HbA1c >5.6%, BP â¥90th %tile, TG â¥150 mg/dl, or HDL <40 mg/dl. Study included 189 subjects, 37.6% were MHO and 62.4% MUO. MHO subjects were younger (mean ± SD, 11.6 ± 3.3 vs 12.9 ± 3.2 years; p < 0.009) and had lower BMI %tile (98.4 ± 1.4 vs 98.8 ± 2.1; p < 0.04), smaller waist (94.2 ± 15.2 vs 101.4 ± 17 cm; p < 0.003) and hip circumferences (105.3 ± 15.6 vs 113.5 ± 15.4 cm; p < 0.001), lower fasting insulin (18.5 ± 10.2 vs 24.2 ± 14.3 μU/ml; p < 0.022), and lower HOMA-IR (4.1 ± 2.4 vs 5.5 ± 3.6; p < 0.022). Acanthosis nigricans was noted less frequently in MHO than MUO (p < 0.005). In stepwise logistic regression, age and BMI %tile were significant predictors of MHO. We found that 38% of obese children are MHO. They are younger and have lower BMI %tiles. Lifestyle modification initiated at an early age may prevent metabolic abnormalities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the National Medical Association - Volume 109, Issue 3, Autumn 2017, Pages 203-210
Journal: Journal of the National Medical Association - Volume 109, Issue 3, Autumn 2017, Pages 203-210
نویسندگان
Aditi M.B.B.S., Vivian M.D., Sheila M.D., Tanni M.D., Shipra M.B.B.S., Elna M.B.B.S., Vatcharapan M.D.,